Mbappe has scored only one goal in his last seven games and has gone over 400 minutes without netting for Real Madrid in all competitions as he continues to struggle playing as a centre forward.
Mbappe was surprisingly dropped for France's fixtures in November after an underwhelming start to life at Real Madrid this season, with Les Bleus coach Didier Deschamps refusing to say why he had not picked his star player.
Kylian Mbappe has fallen out with France coach Didier Deschamps and has no desire to play for the national team under the coach, reports French media.
Real Madrid coach Carlo Ancelotti said his troubled French striker Kylian Mbappe was as down as the rest of the team over recent setbacks but remained motivated ahead of Saturday's Liga clash with Osasuna.
It is the second successive France squad from which the national team captain has been absent after he also missed the October double-header against Israel and Belgium.
Hammered 4-0 by rivals Barcelona in the Clasico at the end of October, Los Blancos slumped to a second consecutive home defeat on Tuesday in Europe, with AC Milan triumphing 3-1 at the Santiago Bernabeu.
Former Real Madrid striker Karim Benzema believes Kylian Mbappe must learn to play as a central striker in the Spanish capital because he cannot displace Vinicius Junior on the left wing.
Robert Lewandowski struck twice in two minutes as Barcelona crushed rivals Real Madrid 4-0 on Saturday, inflicting the Spanish champions' first La Liga defeat in over a year.
Kylian Mbappe's start at Real Madrid has been satisfactory, his performances neither spectacular nor underwhelming, but Saturday's La Liga Clasico offers the French superstar a springboard to kick on from.
Paris Saint-Germain coach Luis Enrique said Tuesday he was chasing history as the club bid for the treble of Ligue 1, Champions League and French Cup trophies this season.
Barcelona woke up with a familiar sinking feeling on Wednesday, another Champions League hangover, after Paris Saint-Germain thrashed them 4-1 at home to eliminate them in the quarter-finals.
Mbappe wrapped up the win in the 89th minute.
"We have no choice. We have to go and win there."
Scorer of 39 goals for his club this season, Mbappe was described as "invisible" against Barcelona by newspaper Le Parisien, which pointed out that he managed just three attempts on goal during the game, none of which troubled Barcelona goalkeeper Marc-Andre ter Stegen.
Barcelona coach Xavi Hernandez hailed his side's 3-2 win away to Paris Saint-Germain in the first leg of their Champions League quarter-final on Wednesday, insisting it showed the Catalans could once again compete with the very best teams in Europe.
The French government said there was no "concrete threat" to Paris Saint-Germain's Champions League match against Barcelona on Wednesday in the French capital after Islamic State threatened to attack all four quarterfinals.
“I am ready and, as always, I am not going to hide. Seeing the dynamic we have, I'm sure we're going to give it our all, then the result... It's in God's hands,” Mbappe told Telefoot
Kylian Mbappe had a penalty saved but then scored the only goal of the game as Paris Saint-Germain beat Rennes 1-0 in the last four of the French Cup on Wednesday to set up a final showdown against Lyon.
Paris Saint-Germain coach Luis Enrique said Tuesday he was "very happy" with star attacker Kylian Mbappe during a press conference on the eve of his side's French Cup semi-final clash with Rennes, as he downplayed rumours of a rift.