Andy Murray cut down Croatian giant Ivo Karlovic to reach the French Open last-16 Friday as two-time Wimbledon champion Petra Kvitova became the fourth top 10 women's seed to be knocked out.

Murray, a three-time semi-finalist, had needed two five-set matches and three days of play to get to the last 32.

But on Friday the 29-year-old needed just a shade under two hours to beat 6ft 11in (2.11m) Karlovic 6-1, 6-4, 7-6 (7/3).

It was his seventh win in seven matches against the 37-year-old as Murray goes on to face John Isner of the United States.

Later yesterday, defending champion Stan Wawrinka reached the last 16 with a 6-4, 6-3, 7-5 win over France's Jeremy Chardy.

The third seed from Switzerland next goes up against Victor Troicki of Serbia for a place in the quarter-finals. He is seeking to become the eighth man in the Open era, since 1968, to successfully defend the title in Paris.

Canada's eighth seed Milos Raonic overcame a left hip injury to defeat Slovakian lucky loser Andrej Martin, the world number 133, and reach the last 16 for a second time.

Raonic won 7-6 (7/4), 6-2, 6-3 but only after requiring a medical timeout at the start of the third set to treat a hip injury.

The Canadian then needed to take a pain-killer before racing away to victory.

Raonic, a quarter-finalist in 2014, next faces 55th-ranked Albert Ramos-Vinolas after the Spaniard stunned American 23rd seed Jack Sock 6-7 (2/7), 6-4, 6-4, 4-6, 6-4.

Spanish fourth seed and last year's Wimbledon runner-up Garbine Muguruza won the last nine games to knock out Belgium's Yanina Wickmayer 6-3, 6-0.