Isner's 500 career tie-break victories put him 34 ahead of Swiss great Roger Federer on the Open Era list, with Pete Sampras (328) third.
Top-ranked Daniil Medvedev committed 11 double-faults in falling to Stefanos Tsitsipas 7-6 (8/6), 3-6, 6-3 in Sunday's semi-finals of the ATP and WTA Cincinnati Masters.
World number one Daniil Medvedev won his first ATP title of 2022 on Saturday, roaring past defending champion Cameron Norrie 7-5, 6-0 in the final of the hardcourt tournament in Los Cabos, Mexico.
World number one Daniil Medvedev, playing his first match in six weeks, beat Australian qualifier Rinky Hijikata 6-4, 6-3 on Wednesday at the ATP hard court tournament in Los Cabos, Mexico.
Rafael Nadal's climb one place to fourth in the world on the strength of his Madrid Masters win was confirmed in the latest ATP rankings released Monday.
Nick Kyrgios overpowered Novak Djokovic for the second time in as many weeks on Wednesday to book an Indian Wells quarter-final against Roger Federer, who swatted aside old foe Rafael Nadal.
Rafael Nadal and Roger Federer booked a mouthwatering fourth-round clash at the ATP Indian Wells Masters on Tuesday, where five-time champion Novak Djokovic also advanced from the "group of death".
Stan Wawrinka breezed into the fourth round of the BNP Paribas Open on Monday and saw another seed removed from his path to the final when lucky loser Yoshihito Nishioka of Japan turned his match against Tomas Berdych upside down.
Novak Djokovic launched his bid for a sixth ATP Indian Wells Masters crown with a two-set triumph over Kyle Edmund as the stars shone in the California desert.
Slovakia's world number six Dominika Cibulkova dropped just two games in blistering heat to win her opening match at the Sydney International on Monday.
Novak Djokovic said he did not intentionally hit a ball into the crowd during his Qatar Open final against Andy Murray, an incident which threatened to take the gloss off his victory.
World number one Andy Murray claimed his 26th consecutive victory on Wednesday with a battling 7-6 (8/6), 7-5 win over Austria's Gerald Melzer to reach the Qatar Open quarter-finals.
Serena Williams suffered a shock second-round defeat at the Auckland Classic Wednesday following her sister Venus's earlier withdrawal with an arm injury.
Andy Murray began 2017 where he left off last year, beating Jeremy Chardy in straight sets in his season opener in Qatar on Tuesday to register his 25th consecutive victory.
World number one Andy Murray insisted Sunday that Novak Djokovic will remain his biggest threat in 2017, as the pair prepare for a potential first clash of the season in Doha this week.
Former world No 1 Ana Ivanovic on Wednesday announced her retirement from tennis, admitting that the physical toll of the circuit had proved too much.
On-going fitness issues have forced Juan Martin del Potro out of next month's Australian Open and his planned warm up event in New Zealand, organisers of the Auckland Classic announced Saturday.