Lewandowski suffered a back injury in Sunday's 1-0 defeat at Real Sociedad during which he had a goal controversially disallowed.
Lewandowski's early disallowed strike led to furious debate over whether the Polish forward had been offside or not.
Barcelona coach Hansi Flick said he thought playmaker Dani Olmo would be ready despite feeling unwell overnight, while defender Pau Cubarsi can play despite suffering a cut on his face during the team's Champions League win over Red Star Belgrade on Wednesday.
It was another commanding victory for LaLiga leaders Barcelona who are in an imperious vein of form, scoring 24 goals in six successive wins in all competitions, including thrashings of Bayern Munich and Real Madrid.
Dani Olmo struck twice for Barcelona on his first start after an injury absence as they beat local rivals Espanyol 3-1 on Sunday to move nine points clear at the top of La Liga.
"Honestly I don't see it as extraordinary, even if some people do... when I was little I also looked on from the outside, watching from my house seeing Messi lift Ballons d'Or and thinking it was incredible. Once you are on the inside, you take it normally, naturally, although if I stop to think about it, it's something really big."
The Catalan giants triumphed at the Santiago Bernabeu to snap Madrid's run of 42 matches unbeaten and continue their own revival under the German coach who arrived this summer.
Defending champions Real Madrid are set to host archrivals Barcelona in a LaLiga game at the Santiago Bernabeu tonight.
Kylian Mbappe's start at Real Madrid has been satisfactory, his performances neither spectacular nor underwhelming, but Saturday's La Liga Clasico offers the French superstar a springboard to kick on from.
The monsoon season usually marks a lull in concert activities, however, musicians and bands from the country are keeping busy with performances overseas. Many music artistes are taking the stage in various countries around the globe, including Europe and the United States.
Images of a young Lionel Messi bathing a four-month-old Lamine Yamal has gone viral on social media recently, with fans astonished to see that Barcelona’s greatest-ever player and the club’s youngest-ever La Liga scorer crossed paths over 16 years ago.
Barcelona appointed Hansi Flick as coach on Wednesday on a deal until June 30, 2026, after sacking Xavi Hernandez last week.
"They should know that they've got a difficult situation, because Barca is a difficult club and there's an adverse financial situation too -- it won't be easy at all," Xavi told DAZN.
Barcelona sacked coach Xavi Hernandez on Friday after the Catalan giants failed to win a trophy this season but just weeks since he and club president Joan Laporta agreed he would stay in the post.
Barcelona forward Robert Lewandowski has suggested he will remain at the LaLiga club next season and said he hopes to contribute to his side's ambitions for silverware.
Spanish media widely reported Friday that Xavi would be sacked in the coming weeks but the coach said Barcelona had "conveyed calmness" to him.
The napkin on which Barcelona promised to sign Lionel Messi when he was a 13-year-old has been sold for 762,400 pounds ($969,000, auction house Bonhams said on Friday.
Catalan radio station RAC-1 said president Joan Laporta had decided to sack Xavi, with daily newspaper Sport confirming the news, while AS said Barcelona were already deciding who would replace the coach.
Lionel Messi's record $20.45 million annual salary from Inter Miami makes him by far the best paid player in Major League Soccer but also puts him ahead of the entire squads of 25 of the league's clubs, according to data released by the MLS Players Association on Thursday.