With Messi sidelined after complaining of a sore right hamstring, and coach Lionel Scaloni serving a one-game suspension, Argentina made nine changes to their starting XI at the Hard Rock Stadium.
Vinicius terrorised Paraguay's defence with his pace and trickery as he scored two goals in an impressive display, a far cry from his performance in Brazil's 0-0 draw with Costa Rica in their opening group stage match, in which he was largely ineffectual.
A wasteful Brazil side dominated possession but were clueless on how to beat an ultra-defensive Costa Rica playing with a back five. They roamed around their opponent's box but were toothless, with just three of their 19 shots on target.
Uruguay's win saw them move level with the United States on three points. The U.S. beat Bolivia 2-0 in the day's other Group C match.
Ecuador were forced to play with 10 men from the 22nd minute of the game at Levi Stadium when striker Enner Valencia was sent off for dangerous play.
The 108-year-old competition is being held in the United States with the host nation among six teams from the CONCACAF region joining the 10 South American nations looking for a place in the July 14 final in Miami.
"It doesn't make much sense to think about when they're gone. Let's enjoy them now, we'll see what happens later. Messi is fine, he's happy. I'm with renewed ideas and strength. It's a nice challenge to defend the title," Scaloni said.
The 48th edition of Copa America, South America's biggest football competition, will be played in the United States from June 20 to July 14, 2024.
“This is a sad moment for those who love Brazilian soccer. It’s getting hard to find the spirit to watch the games. This is perhaps one of the worst teams in recent years, it has no respectable leaders, only average players for the majority."
Doubles from Lionel Messi and Lautaro Martinez earned Argentina a 4-1 victory against Guatemala in their final Copa America warm-up.
Lionel Messi’s Argentina will look to defend their title against the likes of Brazil, Mexico and the United States. Copa America will kick off with Argentina taking on Canada.
The tournament will be held in 14 cities across the United States, from June 20 to July 14, 2024, with each location hosting 2 or 3 games.
"I'm very grateful to God for another opportunity to score for the national team," said Endrick.
Copa America, which runs from June 20 to July 14 hosted by the United States, will have a total of 101 match officials, including eight women.