Even a single point would have flattered Diego Simeone's side but they took all three when the Argentina international, on as a substitute, finished Antoine Griezmann's cross at the back post.
The 24-year-old Argentina international's exit marks a record sale price for City, eclipsing the 50 million pounds Chelsea paid for winger Raheem Sterling in 2022.
The 24-year-old cost City just £14 million when he signed from River Plate in January 2022 and his since enjoyed a meteoric rise, helping Argentina to World Cup and Copa America glory, as well as winning two Premier League titles and the Champions League at club level.
Julian Alvarez celebrated his 24th birthday in style as the Manchester City striker scored twice to inspire a 3-1 win against Burnley on Wednesday.
Fielding a strong side, City suffered a setback when they lost defender Manuel Akanji to injury early in the first half, but Foden's superb finishing and De Bruyne's comeback gave coach Pep Guardiola plenty to be happy about.
Goals by Rodri and Julian Alvarez in each half barely did justice to City's dominance as they enjoyed 84% possession in a routine win that at times resembled a training session.
Alvarez curled his shot from the edge of the box into the top corner in the 84th minute and then set up Doku in stoppage time for their third goal as City, who had lost to Newcastle United in the EFL Cup before their league loss to Wolverhampton Wanderers on Saturday, moved up to six points from two games in top spot
Julian Alvarez and Jeremy Doku came off the bench to grab late goals and push Manchester City to a 3-1 victory at RB Leipzig in the Champions League on Wednesday.
The Premier League, Champions League and FA Cup trophies were all displayed on the pitch before kickoff, after which City comprehensively outplayed Eddie Howe's Newcastle, whose own title aspirations were dealt an early season setback
With Erling Haaland ruled out through a groin issue, the World Cup winner led the City line with aplomb, scoring to level in the first half after Mo Salah had given Liverpool an early lead
Manchester City extended Julian Alvarez's contract to 2028 on Thursday in recognition of an impressive debut season from the Argentine World Cup winner.
South America's top national team competition, the Copa America, will be held in the United States in 2024 and feature 10 teams from South America's CONMEBOL and six teams from the CONCACAF region.
Argentina featured heavily in shortlists for FIFA's Best awards following their World Cup triumph, with forwards Lionel Messi and Julian Alvarez, goalkeeper Emiliano Martinez and coach Lionel Scaloni receiving nominations in their categories.
The 2022 FIFA World Cup in Qatar has entered the knockout phase, and one of the top honours players will be competing for is the Golden Boot, awarded to the player with the most goals in the tournament.
There will be a new look to Manchester City this season but don't expect the transfer movement to disrupt their domination of the Premier League as they defend their crown.
Erling Haaland is determined to get Manchester City over the line in his "favourite tournament" the Champions League this season as the Norwegian superstar was unveiled by the Premier League champions on Sunday.
