La Liga leaders Barcelona stumbled 1-0 at home against Leganes on Sunday as they suffered another blow in the Spanish title race.
Diego Simeone's side have been in fine form and continued their winning run across all competitions with a deserved home triumph, pulling provisionally level with league leaders Barcelona.
Real missed the chance to move above leaders Barcelona in LaLiga as they stay second on 37 points from 17 matches, one behind the Catalans who host Leganes on Sunday when Atletico, in third place on 35 from 16 games, welcome Getafe.
The 23-year-old was forced off with a muscle injury in their 4-0 thrashing of Osasuna at the Bernabeu earlier in November
"We changed the position of the forwards, with Mbappe outside and he did well, like Vinicius inside," said Ancelotti.
Raphinha and Robert Lewandowski's goals put the Catalans in a healthy position but Marc Casado's red card in the 82nd minute helped Celta start the fightback to snatch a point.
Barcelona coach Hansi Flick said Friday he would ask his players if they can win without injured teenage winger Lamine Yamal.
Lewandowski's early disallowed strike led to furious debate over whether the Polish forward had been offside or not.
Hammered by Barcelona in a league Clasico and then outplayed by AC Milan in the Champions League, Carlo Ancelotti's side badly needed this confidence-boosting victory.
The Polish forward struck from close range in the first half to maintain Barca's 100 percent record in the league so far this season with their seventh victory.
Mbappe was taken off after 80 minutes and appeared to be suffering some discomfort, holding the back of his thigh. "He's fine, he's fine, a little overloaded, he asked me for the change to avoid problems," explained Ancelotti.
Hansi Flick's side extended their winning streak in the league to six games as they bounced back from their 2-1 loss against Monaco in the Champions League on Thursday.
Teenage star Lamine Yamal struck twice as La Liga leaders Barcelona thrashed Girona 4-1 on Sunday.
Since scoring in the UEFA Super Cup against Atalanta, new signing Mbappe had failed to find the back of the net in Madrid's opening three games in La Liga, prompting criticism in the Spanish press.
After scoring the first hat-trick of his career and delivering two assists to guide Barca to a 7-0 demolition of Real Valladolid, Raphinha said that the result showed that the club has the players it needs to be contenders.
Signed earlier in the summer from RB Leipzig after playing a central role in Spain's Euro 2024 triumph, the 26-year-old Olmo had to wait two games until Barca could register him due to LaLiga's strict financial control rules.
The goal made Endrick the youngest foreign player to score for Madrid in the Spanish league at 18 years, 35 days, surpassing Frenchman Raphael Varane, who was 18 years, 152 days when he scored in 2011.
Real Madrid midfielder Jude Bellingham sustained a muscle injury during training, the Spanish club said on Friday, and will miss key games for club and country.
Diego Simeone's Atletico Madrid shared an entertaining 2-2 draw with Villarreal as they began their La Liga campaign on Monday.
