Messi's five assists, which all came in the second half, are a new record for an MLS game and he now has 10 goals and 12 assists in eight league appearances so far this season.
Luis Suarez bagged his fifth goal of the season as Inter Miami were held to a 1-1 draw against New York City FC in Major League Soccer on Saturday.
Suarez continued his prolific start to life in MLS with his sixth goal in seven games in all competitions for the South Florida club.
Messi set up Suarez for the eighth-minute opener and then the Argentine found the target himself in the 23rd minute.
Canadian winger Jacob Shaffelburg had put Nashville 2-0 up with a pair of superbly taken goals before Miami's comeback.
Lionel Messi and Inter Miami are ready to push for an MLS Cup title after their pummeling of Orlando City Saturday.
Luis Suarez scored the first two goals of his MLS career.
The addition of Suarez gives Messi a third former Barca teammate on Miami's squad and a much-needed secondary goal-scoring option.
Suarez has won 138 caps for Uruguay since 2007.
Uruguay great Luis Suarez made his second debut for his boyhood club Nacional on Tuesday but could not prevent them from falling to a 1-0 defeat at home to Atletico Goianiense.
Thousands of fans turned out to welcome home Luis Suarez on Sunday as the star striker joined Nacional, the club where he began his storied career 17 years ago.
Former Liverpool and Barcelona forward Luis Suarez has re-joined Uruguayan team Nacional on a free transfer, returning to the Montevideo-based club after 16 years in Europe.
Luis Suarez has entered a pre-contract agreement to join Uruguayan club Nacional as a free agent, the former Liverpool and Barcelona striker said on Tuesday.
Uruguay striker Luis Suarez took his reputation as a fierce competitor to new heights in his side's 1-0 win over Chile in the Copa America on Monday by appealing for a handball -- by Chile's goalkeeper.
Barca player Yerry Mina reveals the training ground bets with Lionel Messi and Luis Suarez.
Surez comes to Uruguay's World Cup quarter-final against France on Friday an all-together wiser and maturer, albeit lacking a bit of the spark and speed of his earlier days.
French forward Antoine Griezmann has always been an admirer of Uruguayan culture and previously stated he is half Uruguayan. But Uruguay striker Luis Suarez do not think so, as he says that on a press conference.
Luis Suarez scores in the 23rd minute as Uruguay beat Saudi Arabia 1-0 in their A fixture at the Rostov Arena today to seal their place in the last 16.
Barcelona beat Valencia 1-0 thanks to a diving header from insatiable striker Luis Suarez to stay on course for a place in the King's Cup final for a record fifth consecutive year.