Mateo Kovacic has undergone surgery on an Achilles injury and will miss the FIFA Club World Cup, Manchester City announced on Monday.
Pep Guardiola said he cannot guarantee Manchester City will be back challenging for the Premier League title next season.
The victory ensured City finish third in the table with 71 points from 38 games, the first time they have ended outside the top two since the 2016-17 season. Fulham finished 11th with 54 points.
De Bruyne was honoured before and after a 3-1 win over Bournemouth as City closed in on qualification for next season's Champions League.
Goals from Omar Marmoush, Bernardo Silva and Nico Gonzalez lifted City up into third in the Premier League heading into Sunday's final round of matches.
With regular taker Erling Haaland on the pitch, it came as a surprise when the Norwegian handed penalty duties to Marmoush. The Egyptian forward hesitated before his spot-kick, and Henderson dived the right way to preserve Palace’s lead.
Guardiola's side will finish without major silverware for the first time in eight years after crashing to a 1-0 defeat against Crystal Palace at Wembley on Saturday.
Eze scored from Palace's very first attack in the 16th minute with a superb finish from Daniel Munoz's cross, after Jean-Philippe Mateta's brilliant hold-up play started the move.
City were deposed as Premier League champions by Liverpool for the first time in five years and are facing a first trophyless season since Guardiola's debut campaign in 2016/17 if they do not beat Crystal Palace in this weekend's showpiece match at Wembley.
Pep Guardiola wants Erling Haaland and his Manchester City team-mates to question if they played with enough hunger during their troubled season.
Manchester City boss Pep Guardiola summed up Kevin De Bruyne's contribution to City's crucial 1-0 victory over Wolverhampton Wanderers on Friday in the same way that he has so many times before -- by saying thanks.
Manchester City moved closer to qualifying for the Champions League as Kevin De Bruyne sealed a vital 1-0 win against Wolves on Friday.
Pep Guardiola says he will take a break from football when he leaves Manchester City but does not know if he will retire from the game.
Manchester City manager Pep Guardiola is glad to have Spain midfielder Rodri back in training but has no idea yet if he will feature at all in this month's FA Cup final, saying "I'm not a doctor".
Manchester City will face Crystal Palace in their third successive FA Cup final after cruising to a 2-0 win against Nottingham Forest at Wembley on Sunday.
Pep Guardiola has vowed Manchester City will be back to their best next season after losing their "spirit" during a turbulent campaign that exposed an unexpected lack of hunger in his side.
Manchester City's Matheus Nunes scored deep in injury time to salvage a crucial 2-1 Premier League victory over Aston Villa on Tuesday in their breathless chase for a Champions League berth next season.
Manchester City manager Pep Guardiola has called on fans to treat their Premier League match against Aston Villa at the Etihad Stadium on Tuesday as a "final" as his side chase qualification for next season's Champions League.
The 33-year-old Belgian, whose deal expires in June, announced on social media this month that he will be leaving City at the end of the season after a decade at the club.
