New head coach Xabi Alonso will make his debut on the Real bench for the Group H match at Hard Rock Stadium and could be without several regulars.
Mbappe has repeated his desire to win Europe's biggest club competition, but the closest the Paris-born forward got with his boyhood club was losing the final in 2020 to Bayern Munich.
After the Catalans scraped a comeback win at Valladolid on Saturday, Madrid survived a late Celta fightback to maintain the four-point gap ahead of next Sunday's Clasico.
Mbappe idolised Ronaldo while growing up and after joining Madrid from Paris Saint-Germain last summer, has equalled the Portuguese striker's tally of 33 goals in his first season at the Santiago Bernabeu.
Mbappe's double took him to 33 strikes in 44 appearances across all competitions, the same number of goals as his idol managed in the 2009-10 campaign.
The French superstar did not train with his team-mates on Tuesday ahead of the game but coach Carlo Ancelotti said the striker would travel to San Sebastian.
The Italian coach said that he was never in doubt that the 26-year-old forward was going to find his form despite a slow start in the Spanish capital after arriving from Paris St Germain, playing in a more centralised role up front.
Speaking on a podcast hosted by former Brazil striker Romario, Neymar blamed a clash of egos for the failure of the three stars to gel during their spell together at the French club.
Busquets, Fernandez, Griezmann, Mbappe, Messi, Muller and more feature as FIFA looks at the World Cup winners set to play at FIFA Club World Cup 2025.
You are what you eat – how true is this statement? Well, whether or not it reflects on us ordinary individuals, for athletes, this directly reflects on their performance. So, what are the top players in the world eating for such power-packed performance on the field?
Kylian Mbappe loves nothing more than carrying the weight of a team on his shoulders and there is evidence he will need to do just that when France start the defence of their World Cup title
Kylian Mbappe scored two goals to help Paris St Germain to a comfortable 3-0 win at Ajaccio on Friday, maintaining their unbeaten run in Ligue 1 this season.
Paris St Germain manager Christophe Galtier said forwards Neymar and Kylian Mbappe share a "very good" relationship, amid reports of a rift between the pair following an incident in their Champions League game this week.
French football giants Paris Saint-Germain faced an angry backlash Tuesday after coach Christophe Galtier and star player Kylian Mbappe mocked a suggestion that they should take the train rather than private planes for short-haul travel.
Kylian Mbappe and Neymar have enjoyed a prolific start to Paris St Germain's new Ligue 1 season and even though they squabbled over who should take penalties, the France forward insisted they had a good relationship.
A leaner and fitter Lionel Messi, similarly rejuvenated Neymar and Kylian Mbappe staying after signing a new contract makes Paris St Germain runaway favourites to retain their Ligue 1 title when the French league season kicks off on Friday.
Real Madrid president Florentino Perez insisted that Paris St Germain forward Kylian Mbappe was not on the club's minds as they celebrated a record-extending 14th European Cup crown after victory against Liverpool in Paris on Saturday.
Neymar says he would like to stay at French champions Paris Saint-Germain despite rarely justifying his world record fee of 222 million euros ($236 million) and amid rumours the club would like him to leave.
Kylian Mbappe said Liverpool were one of the clubs he spoke to before deciding to extend his stay at Paris St Germain, and that he had also met with the Premier League side in 2017 when he was still at Monaco.
