“[We need to] keep going. It's a complicated time,” Messi said in a post-match interview with Apple TV.
The Florida derby defeat leaves Miami with just one win from their last seven games in all competitions and they slip to sixth in the Eastern Conference with Orlando leapfrogging them.
The Argentine scored in the second half but Miami's defence was once again exposed as they fell to a fourth defeat in their last five games in all competitions -- a run which has seen them concede 14 goals.
Miami had lost their last three games, including a 5-1 aggregate defeat to the Vancouver Whitecaps in the Champions Cup semi-finals, but they got a much-needed morale boost with a comfortable Major League Soccer victory.
A dejected-looking Lionel Messi walked off the field in defeat on Wednesday after his Inter Miami team were exposed in emphatic fashion by a young Vancouver Whitecaps.
A crowd of 60,614 turned out at Huntington Bank Field, the home of the NFL's Cleveland Browns, for the visit of Lionel Messi and friends and while the Argentine had a quiet game, Miami left with the points.
A club-record crowd of 62,358 packed into Soldier Field for the visit of Lionel Messi and his Inter team to witness a gutsy display from the home side.
Veteran Haiti international Fafa Picault headed in the winning goal in the 89th minute to give Miami a precious victory that extended their unbeaten start to the season.
Messi provided the assists for both Miami's goals including the leveler which came in the 10th minute of stoppage time.
Lionel Messi's record $20.45 million annual salary from Inter Miami makes him by far the best paid player in Major League Soccer but also puts him ahead of the entire squads of 25 of the league's clubs, according to data released by the MLS Players Association on Thursday.
Inter Miami's five-match winning run came to an end on Wednesday as, without the injured Lionel Messi, they were held to a 0-0 draw at Orlando City.
Olivier Giroud confirmed on Monday that he will leave AC Milan at the end of the season to end his long career in Major League Soccer.
Messi's five assists, which all came in the second half, are a new record for an MLS game and he now has 10 goals and 12 assists in eight league appearances so far this season.
A crowd over 65,612 turned up at Gillette Stadium in Foxborough, Massachusetts, the stadium the Revolution share with the NFL's New England Patriots, to see the Argentine World Cup winner.
France's record goal scorer Olivier Giroud has reached agreement with Los Angeles FC to join the Major League Soccer club this summer, sources close to the player confirmed on Tuesday.
Everything Miami was creating was coming through Messi, who flashed a snapshot wide before moments later whipping in a cross for a Gomez header which was saved by Panicco's feet.
Inter Miami, without Lionel Messi, lost 2-1 at home to Mexico's Monterrey in the first leg of their CONCACAF Champions Cup quarter-final on Wednesday with Argentine Jorge Rodriguez scoring a superb 89th-minute winner.
Luis Suarez bagged his fifth goal of the season as Inter Miami were held to a 1-1 draw against New York City FC in Major League Soccer on Saturday.
The New England Revolution are on track to break a 22-year-old attendance record when Lionel Messi and Inter Miami visit on April 27.
