The group rivals finish the international break level on points, with Germany ahead on goal difference.
Belgium captain Kevin De Bruyne's future with the national side has been thrown into doubt after he slammed his teammates as "not good enough" after a 2-0 Nations League defeat to France.
The Italians built on an impressive win away in France at the weekend as they beat Israel 2-1 in a game played on neutral territory in Budapest due to the security situation in the Middle East.
The 31-year-old Bayern Munich striker, who has scored 66 goals in 99 appearances for England since his debut in 2015, is the first player to become an England men's centurion since striker Wayne Rooney in November 2014.
"This team managed to win a historic match," Spain manager Luis de la Fuente said afterwards.
Ronaldo had reached 900 career goals with his 131st international strike in Thursday's victory over Croatia.
The Dutch were 2-1 up at the break but allowed Bosnia back into the match at 3-2 with some 15 minutes remaining, only to go on and score two late goals for a convincing winning margin.
New-look Germany, who have set their sights on the 2026 World Cup after their quarter-final run at the Euro on home soil in July, no longer have any 2014 World Cup winners in the squad following the international retirements of Thomas Mueller, Toni Kroos and Manuel Neuer.
England interim manager Lee Carsley does not plan to sing the British national anthem before his first game in charge against Ireland in Dublin on Saturday.
Portugal scored twice in five minutes to beat the Czech Republic on Thursday and open up a two-point lead at the top of Group A2 in the Nations League.
Gavi became Spain's youngest scorer ever and Inigo Martinez headed home a late equaliser as Spain drew 2-2 with the Czech Republic in the Nations League in Prague on Sunday.
Cristiano Ronaldo scored twice as Portugal swept to an emphatic 4-0 victory over Switzerland in their UEFA Nations League clash at the Estadio Jose Alvalade in Lisbon on Sunday.
Still something of a novelty, UEFA's inaugural Nations League tournament reaches its final stage with a four-team mini-competition in Portugal this week, which will be short and sharp and looks to be a wide-open contest.