Lyles finished in third place in the 200m on Thursday, dashing his hopes of a sprint double.
Lyles, who had been bidding to complete a 100m-200m double in Paris, was taken off the track in a wheelchair following the race, won by Botswana's Letsile Tebogo.
Tebogo, also a finalist in the 100m, struck a psychological blow to Lyles, crossing the line in 19.96sec, while Lyles timed 20.08sec.
The 27-year-old American catapulted himself into a new level of stardom on Sunday after ending the USA's 20-year wait for a gold medal in the Olympics' most coveted title.
World champion Noah Lyles roared to victory in 9.79sec to claim gold in a dramatic men's Olympic 100m final in Paris on Sunday.
Coached by Carl Lewis and the first European to win the NCAA title in the United States, Hinchliffe finished strongly and Lyles, not exactly easing up, took second in 10.04 to also go through safely.
But the US sprint king tipped to be one of the faces of the Paris Games said Monday that his growing fame has become a problem in the Olympic Village.
"You have to have the mindset of a god," Lyles said of being a top sprinter in "Sprint".
Jamaica's Oblique Seville ran the fastest 100 meters in the world this year, 9.82 seconds, to defeat reigning world champion Noah Lyles on Saturday at the Racer Grand Prix meet.
The Jamaican sprinter left having won 11 world and eight Olympic golds, but now, six years later, it looks as if a rightful successor has emerged: Noah Lyles
Noah Lyles and Sha'Carri Richardson, the two faces of the World Athletics Championships, won their third and second golds respectively by anchoring the United States to 4x100m relay triumphs in Budapest on Saturday.
Lyles, who charged to 100m gold last weekend, clocked 19.52sec for the win with teenage teammate Erriyon Knighton claiming silver in 19.75sec.
Lyles, who already has two world 200m titles to his name and will go for a third in the Hungarian capital, clocked 9.83sec -- the fastest 100m time of the season so far -- for victory.
