Kylian Mbappe scored a screamer and set up another goal as Real Madrid thrashed Sevilla 4-2 on Saturday to move second in La Liga above stuttering rivals Barcelona.
"Sergio Ramos has informed Sevilla FC that he will not stay next season," the club said in a statement.
The player's contract was set to expire at the end of the campaign.
Antoine Griezmann struck a hat-trick in a 3-0 win over 10-man Celta Vigo to help Atletico Madrid climb provisionally second, in hot pursuit of their city rivals.
Sergio Ramos has not played against Real Madrid since 2005 but on Saturday, his Sevilla team welcome the Spanish league leaders to the Sanchez-Pizjuan for a reunion.
Al-Hilal have signed Morocco goalkeeper Yassine Bounou from Spanish side Sevilla on a three-year contract, the Saudi Pro League club said on Thursday.
His message was one of pride, which is what he has restored at Roma, a team which has one of Italy's largest, most passionate fan bases but has won little of note since being founded in 1927.
Sevilla beat AS Roma 4-1 on penalties on Wednesday to win the Europa League for a record-extending seventh time, handing Jose Mourinho his first defeat in six European finals.
Marcus Rashford will miss Manchester United's Europa League quarter-final first-leg clash with Sevilla after suffering a muscle injury that is likely to keep him out for "a few games", the club announced on Wednesday.
Barca's first hurdle en route to the sextuple is a big one as they face Sevilla in the UEFA Super Cup at Georgia.
Barcelona's Dani Alves signs a new two-year deal to remain at FC Barcelona ending rumors of moving to Liverpool or Manchester United.
Champions League winners Barcelona sign Sevilla defender Aleix Vidal for a reported fee of £16m - despite their transfer ban.
Real Madrid superstar Cristiano Ronaldo donates 7 million euros to help the aid effort in Nepal, according to reports in France.
