Djokovic will play Italian 22nd seed Flavio Cobolli in the last eight, with a potential semi-final looming against world number one Jannik Sinner.
Wimbledon fans will have eyes only for the tennis this week but for those who run the world’s oldest and most prestigious Grand Slam, the real high-stakes contest will unfold not on their grass, but in London’s Royal Courts of Justice.
Djokovic's 100 wins puts him behind only Roger Federer's 105 victories in the men's game and nine-time winner Martina Navratilova's all-time record of 120.
The Italian three-time Grand Slam champion eased past his 52nd-ranked opponent 6-1, 6-3, 6-1.
Aryna Sabalenka overcame a fierce challenge from Emma Raducanu and a partisan Centre Court crowd to stay on track for her first Wimbledon title on Friday.
Carlos Alcaraz survived another erratic performance on Friday, battling to a 6-1, 3-6, 6-3, 6-4 win over Germany's Jan-Lennard Struff to stay on track for a third straight Wimbledon crown.
British amateur Oliver Tarvet said facing Carlos Alcaraz at Wimbledon was the "most special day" of his life, but the world number 733 has no intention of turning professional just yet.
After years of having a rather a strained relationship with Wimbledon thanks to being "paralysed by fear" at the thought of playing on tennis's fastest surface, Naomi Osaka feels she has finally found her grasscourt wings.
A record-breaking number of seeds crashed out at the All England Club in the first round, but Alcaraz and women's world number one Sabalenka avoided seismic shocks on Centre Court.
Two-times Wimbledon champion Petra Kvitova has entered the draw for next month's French Open four months after suffering a serious hand injury, she said on Monday.
Two-time Wimbledon champion Petra Kvitova will need at least three months of rest after surgery to her left hand cut by a knife-wielding burglar on Tuesday, her spokesman said.
Andy Murray was voted the BBC Sports Personality of the Year for a record third time on Sunday despite his wife telling him she was voting for one of his rivals.
World number two Novak Djokovic confirms that he has split from his coach Boris Becker after three years working together
Andy Murray reveals the secret behind the personalised notes that fueled his Wimbledon triumph and will inspire his bid for more Olympic glory.
World number one Novak Djokovic is looking forward to playing on his favoured hardcourt surface at the Rogers Cup in Toronto, but the Serb urged caution as he returns to action for the first time since his shock Wimbledon exit.
Wimbledon champion Andy Murray will miss Britain's Davis Cup quarter-final clash against Serbia with captain Leon Smith naming Kyle Edmund and James Ward as his two singles players on Wednesday.
With a record-equalling 22nd Grand Slam title wrapped up, Serena Williams insists she will never get bored of winning and that is bad news for her flagging rivals.
Home star Andy Murray and sentimental favourite Roger Federer will look to the Centre Court crowd on Friday to roar them into the Wimbledon final.
Roger Federer is well short of his best as the seven-time Wimbledon champion advance to the second round with an uninspired victory over Argentina's Guido Pella on Monday.