Spain kept their noses in front of Italy in the fight for automatic qualification for next year's World Cup as David Silva and Diego Costa were on target in a 2-1 win in Macedonia on Sunday.

The two European giants remain locked on 16 points at the top of Group G of UEFA qualifying after Italy saw off Liechtenstein 5-0 in Udine.

However, Spain have a superior goal difference and host the Azzurri in their next qualifier at Real Madrid's Santiago Bernabeu on September 2.

Only the group winners automatically book their place in Russia with second place left to fight out a two-legged playoff in November.

"It is going to be the most important game of the group," Isco told Spanish TV station Teledeporte.

"But we are at home, we hope the Bernabeu will be a fortress and, at the end of the day, it is in our hands."

Victory extends Julen Lopetegui's unbeaten record as Spain boss since replacing Vicente del Bosque just under a year ago, and the visitors looked to be set for an easy night in Skopje after a dominant first 45 minutes.

"We have achieved our objective which was the three points in a difficult game for the time of year," said Lopetegui.

"Other than the goal, we didn't suffer, but it is true that just a one goal difference made us struggle more than expected after seeing the first-half."

Silva has been the talisman of Lopetegui's reign and took his tally to eight goals in his last 10 international caps by finishing off a fine move involving Andres Iniesta and Jordi Alba for the opener on 15 minutes.

Isco was rewarded for his brilliant form towards the end of Real's La Liga and Champions League double-winning campaign with a rare start for his country and looked keen to make an impact.

He stung the palms of Stole Dimitrievski before driving another effort just over the bar.

There was no stopping Isco midway through the half, though, as some sublime skill took him past Kire Ristevski before his low cross was turned home by Costa at the back post.

"I ended the season very strongly and for any player it is important to have the confidence of the coach," added Isco.

"They were three important points against opponents that made things difficult for us and now it is time to rest."

Isco should have added a third before half-time when he dallied before firing too close to Dimitrievski at his near post.

However, Spain looked like a side in need of a rest after a long season as they took their foot well off the gas after the break to allow Macedonia back into the game.

It took an individual moment of brilliance from Stefan Ristovski to give the hosts hope, though, as the right-back charged forward before blasting high into David de Gea's top left-hand corner.

Dimitrievski was forced into one last save four minutes from time to prevent Costa adding a gloss to the scoreline, but Lopetegui's men comfortably saw out the final stages for a hard-earned three points.

Wales manage draw

Aaron Ramsey's penalty helped Wales to a precious 1-1 draw in Serbia in World Cup qualifying on Sunday as they kept their hopes of a place at the finals in Russia alive.

Chris Coleman's side were missing star man Gareth Bale due to suspension in Belgrade but Arsenal midfielder Ramsey inspired the visitors into a half-time lead when he floated in a 35th-minute penalty, sending goalkeeper Vladimir Stojkovic the wrong way.

Ramsey had helped win the penalty by forcing Stojovic into a foul just outside the box as the goalkeeper tried to shepherd the ball behind for a goal-kick -- from Joe Ledley's resulting delivery, Sam Vokes was fouled as he tried to head the ball.

However, substitute Aleksandar Prijovic set up Aleksandar Mitrovic to fire past Wayne Hennessey and equalise in the 73rd minute as Serbia stayed top of qualifying Group D.

"It was a great point. They huffed and puffed a little bit but it wasn't like they were peppering Wayne Hennessey," Coleman told Sky Sports.

"You expect a tough game here. Everything I asked of the players they did it. That's the type of togetherness these boys have got."

Wales are still unbeaten in the group but this was a fifth straight draw and they are third, four points behind both Serbia and the Republic of Ireland, and level on points with Austria in fourth.

Only the group winners qualify automatically for next year's finals, with the eight best runners-up in the nine groups going into play-offs for the last four spots.

Ireland came from behind to draw 1-1 with Austria earlier with Stoke City striker Jon Walters volleying in the equaliser with five minutes left in Dublin.

That goal cancelled out Martin Hinteregger's first-half opener and allowed the Irish to maintain their unbeaten record in qualifying.

It could have been better for Martin O'Neill's side, but there was controversy in the 87th minute as the hosts thought they had won it.

Austrian substitute Florian Grillitsch sliced a corner up into the air inside his own six-yard box and Stefan Lainer helped the ball into his own net under pressure from Shane Duffy on the line.

However, Spanish referee David Fernandez Borbalan disallowed the effort, apparently penalising Duffy for leading with his arm.

"There's nothing wrong with it at all -- he's called a foul on Shane Duffy and I can't see it," said O'Neill.

Ireland are next in action on September 2, when they go to Georgia, who drew 2-2 in Moldova. Those two sides are well adrift at the bottom of the section.