The 36-year-old forward missed Inter Miami's Major League Soccer game at DC United on Saturday after coming off injured in their midweek CONCACAF Champions League win against Nashville.
"A lot of players have never had Old Trafford bouncing like that," said United legend Keane.
Manchester United ended Liverpool's quest for a quadruple of trophies in Jurgen Klopp's final season after Amad Diallo's winner edged a thrilling FA Cup quarter-final 4-3 after extra-time.
Holders City remain on course to repeat their treble triumph of Premier League, Champions League and FA Cup last season as Pep Guardiola's men stretched their unbeaten run in all competitions to 22 games.
Casemiro is the latest absence for Brazil, following injuries to Man City keeper Ederson, Arsenal striker Gabriel Martinelli and Paris St Germain defender Marquinhos, ahead of a match at Wembley on March 23 and one in Madrid's Santiago Bernabeu three days later.
Liverpool head to Old Trafford looking to move a step closer to the second trophy of manager Jurgen Klopp's farewell season
Florian Wirtz scored after 84 seconds as Bayer Leverkusen made it 38 games unbeaten in all competitions with a 3-2 victory in Freiburg on Sunday.
Bangladesh football team landed in Kuwait on Sunday for their World Cup Qualifying round match against Palestine on March 21 after a two-week training camp in Saudi Arabia which included a couple of warm-up matches against higher ranked Sudan.
Carney Chukwuemeka rescued Chelsea with a stoppage-time strike that inspired a 4-2 win over 10-man Leicester in an FA Cup quarter-final thriller on Sunday.
Bundesliga strugglers Wolfsburg fired manager Niko Kovac on Sunday with the German side yet to win in the league since the start of the year.
Barcelona coach Xavi Hernandez said on Saturday PSG were the favourites in their upcoming Champions League quarter-final tussle.
Real Madrid are a different side compared to last season thanks to midfielder Jude Bellingham's "obvious" impact, Manchester City manager Pep Guardiola said after his side were drawn to face the LaLiga club in the Champions League quarter-finals.
Cristiano Ronaldo, who had just recently become the first footballer to achieve 800 career wins, was included in the Portugal squad for the upcoming friendly matches against Sweden and Slovenia.
Spanish club Real Madrid announced Friday that it had filed a complaint regarding the racist insults made against Vinicius Junior before Atletico Madrid and Barcelona's midweek Champions League matches.
“The camp, like the previous year’s one, was a great experience for the team and definitely, we are better team than what we were before coming here. We are little closer to the Palestine tie and we will be ready for March 21,” Cabrera was quoted as saying in a video footage sent by Bangladesh Football Federation.
De Bruyne has been left out of Belgium's squad for their forthcoming friendlies against the Republic of Ireland and England because of a groin strain.