Sri Lanka's Matheesha Pathirana took four wickets while Bangladesh's Mustafizur Rahman took one for 55 as Chennai Super Kings beat Mumbai Indians by 20 runs in a heavyweight IPL clash at the Wankhede on Sunday. 

Pathirana, back from an injury, ripped through the Mumbai batting, and even as Rohit Sharma hit an unbeaten 105, the hosts fell well short.

Set 207 for victory, five-time winners Mumbai finished on 186-6 even though Rohit raised his ton in 61 balls at his home in Wankhede Stadium.

Skipper Ruturaj Gaikwad and the in-form Shivam Dube powered Chennai, who won their fifth title last year, to 206-4.

Gaikwad hit 69 and Dube smashed an unbeaten 66 before warhorse M.S. Dhoni smashed three successive sixes in the 20th over to take Chennai past 200.

Dhoni came in to bat with four balls left and scored 20. He smashed Mumbai skipper Hardik Pandya for three sixes and finished with a two to end a 26-run over.

Pathirana then took four wickets to push Mumbai to their fourth loss of the season.

The two teams are on contrasting runs after changes of guard this season. Pandya replaced Rohit as Mumbai captain  while Dhoni surprisingly handed over the Chennai leadership to Gaikwad.

Gaikwad had his fourth win as captain after he set the pace for his team with his 40-ball knock laced with five fours and five sixes.

He put on 90 runs with Dube before falling to Pandya, but Dube and then Dhoni's cameo ensured Chennai finished strongly.

Mumbai started well with Rohit and Ishan Kishan putting together 70 runs for the first wicket before Pathirana hit back.

Pathirana, known "Baby Malinga" for his slinging action similar to former Sri Lankan quick Lasith Malinga, sent back Kishan and then Suryakumar Yadav, for his second duck this season, in the space of three balls.

He later dismissed Tilak Varma for 31 as Rohit attempted to keep up the charge in his 63-ball knock and his second IPL ton.

Tushar Deshpande got Pandya out and the home crowd cheered in another sign of growing unpopularity of Mumbai's choice of captain.

Mustafizur, meanwhile, didn't have a memorable return to his former franchise as he was taken for 55 runs -- his worst figures in Chennai colours -- while grabbing the wicket of Tim David. 

Fizz, however, took a brilliant catch on the ropes to dismiss Suryakumar Yadav off Pathirana.