Lionel Messi scored twice and created another for Sergio Busquets as Inter Miami beat Nashville 3-1 on Saturday to maintain top spot in Major League Soccer's Eastern Conference.

Miami suffered an early setback when their defender Franco Negri deflected a corner from Daniel Lovitz into his own net in just the second minute of the game at Chase Stadium.

Gerardo Martino's team have now failed to keep a clean sheet in each of their last eleven games and it could have been worse when three minutes later Josh Bauer blasted a shot against the bar.

But Messi soon had Miami on level terms -- the Argentine set free by a clever flick from Diego Gomez saw a shot parried out by Nashville keeper Elliot Panicco, but after Luis Suarez directed the loose ball back to him Messi slotted home to make it 1-1 in the 11th minute.

Two minutes later, Messi took advantage of some sloppy play from Nashville but his low right-foot shot came out off the post.

Everything Miami was creating was coming through Messi, who flashed a snapshot wide before moments later whipping in a cross for a Gomez header which was saved by Panicco's feet.

Six minutes before the interval, Messi's former Barcelona team-mate Busquets found the net for the first time in MLS, meeting the World Cup winner's corner with a fine glancing header at the near post.

But there was a blow for the home side just before the break when Paraguay international Gomez was stretchered off, the latest in a series of injuries for Miami.

His replacement, Brazilian born youngster Leonardo Afonso, had the ball in the net but his effort was ruled out for offside.

Nashville came out strongly after the break but despite dominating possession for the opening 20 minutes of the half, they had little to show for their efforts other than a couple of off-target long-range efforts from German Hany Mukhtar.

Nine minutes from the end, Miami were able to put the game to bed when Afonso was ruled to have been brought down inside the box by Bauer and Messi slotted home the penalty.

The goal was Messi's ninth goal in as many games in all competitions this season for Miami.