France and Turkey have said that air strikes on hospitals in northern Syria constitute war crimes.

Up to 50 people have been killed in missile attacks on schools and hospitals in the region, the UN said.

Turkey's foreign ministry blamed Russia for the attacks. Moscow is yet to respond to the allegations.

Meanwhile, Syrian President Bashar al-Assad has cast doubt over plans to implement a "cessation of hostilities" in Syria.

Last week world powers agreed to work towards a selective truce in Syria, to begin later this week.

But in his first comments on the announcement, President Assad said such a ceasefire did not mean all the parties would put down their weapons.

"So far they say they want a ceasefire within a week," he said in televised comments.

"Who is capable of gathering all these conditions and requirements within a week?"

The UN said the series of raids in northern Syria "cast a shadow" on the prospects for a cessation.

At least 12 people were killed in Azaz and the surrounding area, with two hospitals and two schools reportedly hit.

In Maarat al-Numan, in Idlib province, a hospital run by Medecins Sans Frontieres (MSF ) was reduced to rubble.

Seven people were killed and another eight are still missing the medical charity said, calling it a "deliberate" attack.

-International humanitarian law bans any attack on patients and medical personnel or indeed any attack on medical facilities, which are zones that must be respected under the rules of war

-Even if combatants take refuge in them, they should not be attacked

-Under rules established by the International Criminal Court, any such incident would probably result in too high a number of civilian casualties - what is called the rule of proportionality

Mego Terzian, president of MSF France, told Reuters "either the [Syrian] government or Russia" was responsible.

But the Syrian ambassador to Moscow Riad Haddad, said the US was to blame, a claim the Pentagon dismissed as "patently false".

"We have no reason to strike in Idlib, as Isil (so-called Islamic State) is not active there," spokesman Capt Jeff Davis said.

A second hospital in Maarat al-Numan was also hit, killing three people, activists said.

'Obvious war crimes'

France said it condemned the bombing of the MSF clinic in the strongest terms, with Foreign Minister Jean-Marc Ayrault saying such acts "constitute war crimes".

Turkey called the attacks "obvious" war crimes. Relations between Turkey and Russia are badly strained, with the pair on opposite sides of the Syrian conflict.

Russia has been backing the Syrian government in its offensive against rebels but says it only targets what it calls "terrorists".

Meanwhile, Kurdish forces have captured the town of Tal Rifaat from Islamist rebels in northern Syria, the monitoring group the Syrian Observatory for Human Rights said.

This was despite three days of shelling from Turkey, which views the YPG militia in Syria as allied to the outlawed PKK, which has carried out a decades-long campaign for autonomy in Turkey.

Turkish Prime Minister Ahmet Davutoglu promised the "harshest reaction" if Kurdish forces tried to take nearby Azaz.

The militia has taken advantage of the chaotic situation to extend its territory near the border, just as a Syrian government offensive threatens to surround Aleppo further south.

The UN envoy to Syria, Staffan de Mistura, is in the Syrian capital Damascus as part of his effort to restart peace talks.

Almost five years of civil war in Syria have led to the deaths of more than 250,000 people. More than 11 million people have been displaced.