Isner's 500 career tie-break victories put him 34 ahead of Swiss great Roger Federer on the Open Era list, with Pete Sampras (328) third.
Top-ranked Daniil Medvedev committed 11 double-faults in falling to Stefanos Tsitsipas 7-6 (8/6), 3-6, 6-3 in Sunday's semi-finals of the ATP and WTA Cincinnati Masters.
World number one Daniil Medvedev won his first ATP title of 2022 on Saturday, roaring past defending champion Cameron Norrie 7-5, 6-0 in the final of the hardcourt tournament in Los Cabos, Mexico.
World number one Daniil Medvedev, playing his first match in six weeks, beat Australian qualifier Rinky Hijikata 6-4, 6-3 on Wednesday at the ATP hard court tournament in Los Cabos, Mexico.
Rafael Nadal's climb one place to fourth in the world on the strength of his Madrid Masters win was confirmed in the latest ATP rankings released Monday.
Nick Kyrgios overpowered Novak Djokovic for the second time in as many weeks on Wednesday to book an Indian Wells quarter-final against Roger Federer, who swatted aside old foe Rafael Nadal.
Rafael Nadal and Roger Federer booked a mouthwatering fourth-round clash at the ATP Indian Wells Masters on Tuesday, where five-time champion Novak Djokovic also advanced from the "group of death".
Stan Wawrinka breezed into the fourth round of the BNP Paribas Open on Monday and saw another seed removed from his path to the final when lucky loser Yoshihito Nishioka of Japan turned his match against Tomas Berdych upside down.
Novak Djokovic launched his bid for a sixth ATP Indian Wells Masters crown with a two-set triumph over Kyle Edmund as the stars shone in the California desert.
Rafael Nadal booked his semi-final spot at the Mexico Open by battling past Yoshihito Nishioka in straight sets, while top seed Novak Djokovic suffered another stunning exit in a shaky start to 2017.
Roger Federer showed few signs of rust after a month off following his Australian Open heroics in sending Benoit Paire packing at the Dubai Tennis Championships on Monday.
Top-seeded Canadian Milos Raonic held off Juan Martin del Potro 6-3, 7-6 (8/6) on Saturday to book a title clash with Jack Sock at the ATP Delray Beach Open.
World number two Novak Djokovic will make his return from a shoulder injury at next week's ATP tournament in Acapulco, the Serb said on Friday.
Canadian top seed Milos Raonic advanced to the quarter-finals of the ATP Delray Beach Open on Wednesday by defeating Croatia's Borna Coric 6-3, 7-6 (7/2).
Former US Open champ Juan Martin Del Potro got his season off to another successful start at the Delray Beach Open, defeating Kevin Anderson in straight sets and overcoming an opening set tumble in the process.
Japanese top seed Kei Nishikori lost a sixth successive final on Sunday when he was defeated by Ukraine's Alexandr Dolgopolov 7-6 (7/4), 6-4 in the Buenos Aires clay-court title match.
With Novak Djokovic's reign broken, Andy Murray boosted his claim to the Melbourne Park throne with a comprehensive 6-4 6-2 6-4 win over American Sam Querrey to reach the fourth round of the Australian Open on Friday.
Uzbek Denis Istomin pulled off an Australian Open upset for the ages when he sent reigning champion Novak Djokovic tumbling out of the year's first grand slam in a near five-hour epic on Thursday.
World number one Andy Murray could face challenges from Kei Nishikori and Stan Wawrinka if he is to reach a sixth Australian Open final following Friday's draw.