A brace from Amad Diallo gave United their first success in this season's competition, coming under interim manager Ruud van Nistelrooy after they had drawn the previous three games with Erik ten Hag was in charge.
Tottenham Hotspur made it three wins from three in the Europa League with a 1-0 win at home to AZ on Thursday but Manchester United remain winless after being held to a 1-1 draw at red-carded Jose Mourinho's Fenerbahce.
Manchester United manager Erik ten Hag has highlighted a lack of goals as the major factor behind the English giants' faltering start to the season.
Manchester United manager Erik ten Hag said his side had failed to maintain their intensity in Wednesday's 1-1 Europa League draw with FC Twente and should have pushed to kill the visitors off before they had the chance to equalise.
Erik ten Hag made a convincing case to be spared the sack as Manchester United upset Manchester City to take the FA Cup with a shock 2-1 victory in Saturday's final.
Leverkusen - or 'Neverlusen' as they had been dubbed after obliterating Bayern Munich's 11-year Bundesliga title monopoly in Germany - can still win a domestic double with victory against second-tier Kaiserslautern in Saturday's German Cup final.
Gian Piero Gasperini lavished praise on his "incredible" Atalanta players after they stunned Bayer Leverkusen to win the Europa League and claim their first ever continental honour.
Ademola Lookman scored a stunning hattrick as Atalanta ended Bayer Leverkusen's 51-match unbeaten run to win the Europa League final 3-0 on Wednesday and claim their first trophy for 61 years.
Bayer Leverkusen had won only two major trophies in their 119-year history before this season but on Wednesday the newly-crowned Bundesliga champions have the chance to claim a double when they face Atalanta in the Europa League final in Dublin.
Ajax Amsterdam, trailing 3-0 and down to 10 men, scored two late goals to overcome Schalke 04 in the Europa League quarter-finals on Thursday while Olympique Lyonnais won a 16-kick penalty shootout against Besiktas.
Manchester United needed an extra-time winner from Marcus Rashford to defeat Anderlecht 2-1 at Old Trafford on Thursday and move into the last four of the Europa League with a 3-2 aggregate victory.
Playing in the Europa League final in Sweden next month would be the "perfect" way to end a difficult season for Manchester United, manager Jose Mourinho has said ahead of his side's quarter-final second leg against Anderlecht on Thursday.
Manchester United should focus on winning the Europa League this season, which would bring the club a trophy they have never won and secure qualification for next season's Champions League, former manager Alex Ferguson has said.
Fiorentina squandered a two-goal lead at home for the second time in five days on Monday and were jeered off the field following a 2-2 draw with Torino which heaped the pressure on coach Paulo Sousa.
Tottenham Hotspur's Europa League hopes were crushed by mid-table Belgian side Gent, who booked their spot in the last 16 with a 2-2 draw at Wembley on Thursday as the hosts paid the penalty for Dele Alli's first-half red card.
Manchester United manager Jose Mourinho admitted he was frustrated by his side's over-confident approach to the first half of the 3-0 Europa League round-of-32 first-leg win over French side St Etienne on Thursday.
Inter Milan's calamitous season hit a new low on Thursday as they squandered a two-goal lead to lose 3-2 at Israeli club Hapoel Beer-Sheva and suffer the embarrassment of an early Europa League exit.
An angry Wayne Rooney was adamant last weekend that his critics in the media were trying to write his sporting obituary.
Manchester United suffer defeat in their opening Europa League group game, while Premier League rivals Southampton win.