The French superstar believes he was sidelined by PSG and made to train with players the club were trying to offload after refusing to agree a new contract.
New head coach Xabi Alonso will make his debut on the Real bench for the Group H match at Hard Rock Stadium and could be without several regulars.
Mbappe has repeated his desire to win Europe's biggest club competition, but the closest the Paris-born forward got with his boyhood club was losing the final in 2020 to Bayern Munich.
After the Catalans scraped a comeback win at Valladolid on Saturday, Madrid survived a late Celta fightback to maintain the four-point gap ahead of next Sunday's Clasico.
Mbappe idolised Ronaldo while growing up and after joining Madrid from Paris Saint-Germain last summer, has equalled the Portuguese striker's tally of 33 goals in his first season at the Santiago Bernabeu.
Mbappe's double took him to 33 strikes in 44 appearances across all competitions, the same number of goals as his idol managed in the 2009-10 campaign.
The French superstar did not train with his team-mates on Tuesday ahead of the game but coach Carlo Ancelotti said the striker would travel to San Sebastian.
The Italian coach said that he was never in doubt that the 26-year-old forward was going to find his form despite a slow start in the Spanish capital after arriving from Paris St Germain, playing in a more centralised role up front.
Speaking on a podcast hosted by former Brazil striker Romario, Neymar blamed a clash of egos for the failure of the three stars to gel during their spell together at the French club.
Tottenham goalkeeper Lloris brought an end to his international career in January after losing the World Cup final a month earlier
Paris St Germain suffered yet another setback as they slumped to their first Ligue 1 home defeat of the season when they were beaten 2-0 by Stade Rennais on Sunday.
PSG have been left with just the Ligue 1 title to play for in the remaining months of the season after the Qatar-owned club were knocked out of Europe's elite club competition in the last 16 with a 3-0 aggregate defeat
Paris Saint-German forward Neymar arrived in Doha on Friday for an operation on the ankle injury that has ended his season, Qatar's official news agency said.
PSG, trailing 1-0 from the first leg in Paris, were beaten 2-0 in the return game at the Allianz Arena to drop out of the competition in the last 16 for the fifth time in seven seasons
Eric Maxim Choupo-Moting scored against his former club as Bayern Munich ended the Champions League hopes of Paris Saint-Germain on Wednesday, beating the French club 2-0 in their last-16 second leg to reach the quarter-finals.
Bayern Munich host Paris Saint-Germain on Wednesday with the stage set for star turns from their 2022-23 additions Sadio Mane and Matthijs de Ligt.
"It stays in the back of my mind, which is normal. If I keep going like this, I don't think I'll be very far off it,"
The ceremony takes place in Paris, and Messi appears as the favourite to add another individual gong to his collection after leading Argentina to glory over Mbappe's France in that epic encounter in Qatar.
On Saturday, coach Christophe Galtier said he did not think Mbappe would play on Tuesday
