The 39-year-old winger -- Sevilla and the Spanish national team's most-decorated player -- will officially retire when his contract expires on December 31 due to a painful and chronic hip injury which has plagued him in recent seasons.
Kylian Mbappe scored a screamer and set up another goal as Real Madrid thrashed Sevilla 4-2 on Saturday to move second in La Liga above stuttering rivals Barcelona.
"Sergio Ramos has informed Sevilla FC that he will not stay next season," the club said in a statement.
The player's contract was set to expire at the end of the campaign.
Antoine Griezmann struck a hat-trick in a 3-0 win over 10-man Celta Vigo to help Atletico Madrid climb provisionally second, in hot pursuit of their city rivals.
Sergio Ramos has not played against Real Madrid since 2005 but on Saturday, his Sevilla team welcome the Spanish league leaders to the Sanchez-Pizjuan for a reunion.
Al-Hilal have signed Morocco goalkeeper Yassine Bounou from Spanish side Sevilla on a three-year contract, the Saudi Pro League club said on Thursday.
His message was one of pride, which is what he has restored at Roma, a team which has one of Italy's largest, most passionate fan bases but has won little of note since being founded in 1927.
Sevilla beat AS Roma 4-1 on penalties on Wednesday to win the Europa League for a record-extending seventh time, handing Jose Mourinho his first defeat in six European finals.
Luis Suarez insists the Spanish Super Cup is not Barcelona's yet after helping his team shoot down Sevilla 2-0 to give them a comfortable lead after the first leg of the final.
Barcelona coach Luis Enrique has a tough decision to make before his side's first game of the season against Sevilla in the Spanish Super Cup first leg on Sunday.
France have called up Sevilla defender Adil Rami as cover for Raphael Varane, the French football federation says Monday.
Spanish side Sevilla fight back with three second-half goals against Liverpool to win their third successive Europa League trophy.
Barcelona president Josep Maria Bartomeu says star forward Lionel Messi is on course to be fit to face Real Madrid on November 21.
Premier League leaders Manchester City travel to Europa League holders Sevilla on Tuesday intent on proving they won't be Champions League flops once more this season.
Maradona was chosen number 1 in The Greatest 10 World Cup players of all time by the London-based newspaper The Times. On his 55th birthday, discover the life of Diego Maradona, the footballer as he carved out a special place for himself with his unique talent and skills.
A Barcelona side without the injured Lionel Messi head to face Sevilla at Estadio Ramon Sanchez Pizjuan on Saturday, desperate to move back to the summit of La Liga.
Barcelona star Lionel Messi will be back in action before the two months originally stipulated, Argentina team doctor Donato Villani has said.
Barcelona coach Luis Enrique says that Lionel Messi's penalty issues do not make the Blaugrana superstar seem any less of a visitor from another planet.
