With Roger Federer retired and Rafael Nadal struggling to get back on court due to injuries, Novak Djokovic was the last man of that golden generation standing at Flushing Meadows, but the Serb crashed out in the third round to Australian Alexei Popyrin.
Jannik Sinner produced a brutal display of baseline power as he became the first Italian man to win the US. Open with a 6-3, 6-4, 7-5 win over American Taylor Fritz in the final on Sunday.
"I'm speechless right now. So many times I thought I was so close to get the US Open title. It has always been a dream of mine and finally I got this beautiful trophy," said Sabalenka.
Frances Tiafoe blamed his heartbreaking five-set US Open semi-final defeat to Taylor Fritz on cramping after his "body shut down".
Taylor Fritz fought back to defeat compatriot Frances Tiafoe at the US Open on Friday, becoming the first American man to reach a Grand Slam final in 15 years.
Italian top seed Jannik Sinner took down ailing Briton Jack Draper 7-5, 7-6 (7/3), 6-2 to reach the US Open final on Friday, overcoming muggy conditions in a chaotic match at Arthur Ashe Stadium.
World number one Jannik Sinner reached his first US Open semi-final on Wednesday with a four-set victory over 2021 champion and two-time runner-up Daniil Medvedev.
Jessica Pegula became the fourth American to reach this year's US Open semifinals on Wednesday by stunning world number one Iga Swiatek as Jack Draper broke through to his first Grand Slam last-four.
Top seed Swiatek, who won the title two years ago, showcased her all-court game in a straightforward 6-4, 6-1 win over Russian Liudmila Samsonova to open the evening session at Arthur Ashe Stadium and warned she was only going to improve.
Simona Halep does something no one else was able to do against Serena Williams at the U.S. Open but still cannot not stop the world number one from advancing to the semi-finals.
Kei Nishikori stunned Andy Murray to reach the US Open semi-finals, holding his nerve in a breathtaking final set to move two wins away from becoming the first Asian man to capture a Grand Slam singles title.
Novak Djokovic's path to a 10th successive US Open semi-final has been a strange one, but the world number one isn't complaining.
Gael Monfils is back in a Grand Slam semi-final after an eight-year wait after pummelling fellow Frenchman Lucas Pouille 6-4, 6-3, 6-3 to reach the US Open last four.
Angelique Kerber reaches her second US Open semifinal on Tuesday with a 7-5, 6-0 win over Roberta Vinci which also edged her closer to the world number one spot.
Second seed and 2012 champion Andy Murray crushes Bulgaria's Grigor Dimitrov 6-1, 6-2, 6-2 to reach a sixth US Open quarter-final.
Serena Williams storms into the US Open quarter-finals in record-smashing style by easing past Kazakhstan's Yaroslava Shvedova 6-2 6-3 to claim her record 308th grand slam match win,
14-time Grand Slam champion Rafael Nadal crashes out of the US Open, falling in a five-set thriller to 22-year-old Frenchman Lucas Pouille.
Venus Williams moves within two wins of a possible sisterly showdown with Serena in the semi-finals of the U.S. Open by beating German 26th seed Laura Siegemund.
A tearful Nick Kyrgios, a dark horse to win the US Open, retires from his third-round match against Ukraine's Illya Marchenko with a hip injury.