With Roger Federer retired and Rafael Nadal struggling to get back on court due to injuries, Novak Djokovic was the last man of that golden generation standing at Flushing Meadows, but the Serb crashed out in the third round to Australian Alexei Popyrin.
Jannik Sinner produced a brutal display of baseline power as he became the first Italian man to win the US. Open with a 6-3, 6-4, 7-5 win over American Taylor Fritz in the final on Sunday.
"I'm speechless right now. So many times I thought I was so close to get the US Open title. It has always been a dream of mine and finally I got this beautiful trophy," said Sabalenka.
Frances Tiafoe blamed his heartbreaking five-set US Open semi-final defeat to Taylor Fritz on cramping after his "body shut down".
Taylor Fritz fought back to defeat compatriot Frances Tiafoe at the US Open on Friday, becoming the first American man to reach a Grand Slam final in 15 years.
Italian top seed Jannik Sinner took down ailing Briton Jack Draper 7-5, 7-6 (7/3), 6-2 to reach the US Open final on Friday, overcoming muggy conditions in a chaotic match at Arthur Ashe Stadium.
World number one Jannik Sinner reached his first US Open semi-final on Wednesday with a four-set victory over 2021 champion and two-time runner-up Daniil Medvedev.
Jessica Pegula became the fourth American to reach this year's US Open semifinals on Wednesday by stunning world number one Iga Swiatek as Jack Draper broke through to his first Grand Slam last-four.
Top seed Swiatek, who won the title two years ago, showcased her all-court game in a straightforward 6-4, 6-1 win over Russian Liudmila Samsonova to open the evening session at Arthur Ashe Stadium and warned she was only going to improve.
Twice grand slam winner Stan Wawrinka rallies from 5-2 down in the second set to clinch victory over Italian Alessandro Giannessi and reach the third round of the U.S. Open.
Novak Djokovic, well rested after not playing since Monday, resumes his US Open title defence against fiery Russian Mikhail Youzhny, a two-time semi-finalist in New York.
World number two Andy Murray made himself heard at the US Open on Thursday, downing tenacious Spaniard Marcel Granollers in straight sets to reach the third round.
World number one Serena Williams opens her U.S. Open account with a tidy 6-3 6-3 win over Ekaterina Makarova.
Second seed Andy Murray has always said he would quite like an indoor grand slam event and at the U.S. Open it seems he has found the next best thing.
Tennis star Nick Kyrgios has threatened to quit his sport so many times the throw away declarations barely raise the eyebrows
Kei Nishikori, glad to be back on the New York hard courts where he became Asia's first men's Grand Slam finalist, reaches the second round of US Open.
Monica Puig, whose Olympic tennis triumph in Rio de Janeiro gave Puerto Rico their first ever Games gold, is unceremoniously bundled out of the US Open.
Novak Djokovic opens defence of his U.S. Open title with a laboured 6-3 5-7 6-2 6-1 win over Poland's Jerzy Janowicz that brings new concerns about the world number one's fitness.
Rafael Nadal and Angelique Kerber shrug off sweltering temperatures to reach the US Open second round as Garbine Muguruza survives a worrying health scare.