With Roger Federer retired and Rafael Nadal struggling to get back on court due to injuries, Novak Djokovic was the last man of that golden generation standing at Flushing Meadows, but the Serb crashed out in the third round to Australian Alexei Popyrin.
Jannik Sinner produced a brutal display of baseline power as he became the first Italian man to win the US. Open with a 6-3, 6-4, 7-5 win over American Taylor Fritz in the final on Sunday.
"I'm speechless right now. So many times I thought I was so close to get the US Open title. It has always been a dream of mine and finally I got this beautiful trophy," said Sabalenka.
Frances Tiafoe blamed his heartbreaking five-set US Open semi-final defeat to Taylor Fritz on cramping after his "body shut down".
Taylor Fritz fought back to defeat compatriot Frances Tiafoe at the US Open on Friday, becoming the first American man to reach a Grand Slam final in 15 years.
Italian top seed Jannik Sinner took down ailing Briton Jack Draper 7-5, 7-6 (7/3), 6-2 to reach the US Open final on Friday, overcoming muggy conditions in a chaotic match at Arthur Ashe Stadium.
World number one Jannik Sinner reached his first US Open semi-final on Wednesday with a four-set victory over 2021 champion and two-time runner-up Daniil Medvedev.
Jessica Pegula became the fourth American to reach this year's US Open semifinals on Wednesday by stunning world number one Iga Swiatek as Jack Draper broke through to his first Grand Slam last-four.
Top seed Swiatek, who won the title two years ago, showcased her all-court game in a straightforward 6-4, 6-1 win over Russian Liudmila Samsonova to open the evening session at Arthur Ashe Stadium and warned she was only going to improve.
Novak Djokovic, who won his 24th Grand Slam title on Sunday, will dominate men's tennis for years because younger players have yet to reach his level, according to Andy Murray.
"I thought about doing this t-shirt a few days ago," said Djokovic. "I didn't share it with anybody. Kobe was a close friend of mine, we chatted a lot, about the winner's mentality."
The 36-year-old Serb becomes the oldest U.S. Open men’s winner in the Open Era and the first to win three Grand Slam events in a season for the fourth time.
Gauff, 19, produced a gutsy performance on the Arthur Ashe Stadium court to win 2-6, 6-3, 6-2 in 2hr 6min to complete a fairytale transformation in her season's fortunes.
Novak Djokovic earned himself another shot at a record-equalling 24th Grand Slam title after beating unseeded American Ben Shelton in straight sets on Friday to advance to his 10th US Open final.
Daniil Medvedev upset defending champion Carlos Alcaraz in an enthralling semi-final duel to reach the US Open final on Friday.
Aryna Sabalenka fought back from the brink of defeat to overcome American 17th seed Madison Keys in a third-set tie-break and line up a US Open final against home favourite Coco Gauff.
The US Open was plunged into chaos on Thursday after environmental activists disrupted play, forcing a 49-minute stoppage as the tennis showpiece became the latest high-profile sporting event to be targeted by protesters.
American teenager Coco Gauff shrugged off a 50-minute stoppage caused by climate protesters to power into the US Open final on Thursday with a straight sets defeat of Karolina Muchova.
Defending champion Alcaraz moved to within one win of a potential dream final with Novak Djokovic with an emphatic straight sets victory over German 12th Alexander Zverev.