With Roger Federer retired and Rafael Nadal struggling to get back on court due to injuries, Novak Djokovic was the last man of that golden generation standing at Flushing Meadows, but the Serb crashed out in the third round to Australian Alexei Popyrin.
Jannik Sinner produced a brutal display of baseline power as he became the first Italian man to win the US. Open with a 6-3, 6-4, 7-5 win over American Taylor Fritz in the final on Sunday.
"I'm speechless right now. So many times I thought I was so close to get the US Open title. It has always been a dream of mine and finally I got this beautiful trophy," said Sabalenka.
Frances Tiafoe blamed his heartbreaking five-set US Open semi-final defeat to Taylor Fritz on cramping after his "body shut down".
Taylor Fritz fought back to defeat compatriot Frances Tiafoe at the US Open on Friday, becoming the first American man to reach a Grand Slam final in 15 years.
Italian top seed Jannik Sinner took down ailing Briton Jack Draper 7-5, 7-6 (7/3), 6-2 to reach the US Open final on Friday, overcoming muggy conditions in a chaotic match at Arthur Ashe Stadium.
World number one Jannik Sinner reached his first US Open semi-final on Wednesday with a four-set victory over 2021 champion and two-time runner-up Daniil Medvedev.
Jessica Pegula became the fourth American to reach this year's US Open semifinals on Wednesday by stunning world number one Iga Swiatek as Jack Draper broke through to his first Grand Slam last-four.
Top seed Swiatek, who won the title two years ago, showcased her all-court game in a straightforward 6-4, 6-1 win over Russian Liudmila Samsonova to open the evening session at Arthur Ashe Stadium and warned she was only going to improve.
Australia's Nick Kyrgios sent defending champion Daniil Medvedev tumbling out of the US Open on Sunday as US teenager Coco Gauff reached the quarter-finals for the first time.
Serena Williams' dreams of a fairytale finish to her glittering career were dashed on Friday as the tennis icon was sent crashing out of the US Open by Australia's Ajla Tomljanovic.
Rafael Nadal overcame a freak injury scare when he accidentally hit himself with his own racquet to reach the US Open third round on Thursday.
The U.S. Open turned over Arthur Ashe Stadium to the Williams sisters on Thursday for a prime-time first round doubles match that could have been Serena's last after the pair fell 7-6 (5), 6-4 to the Czech duo of Lucie Hradecka and Linda Noskova.
World number one Daniil Medvedev maintained his strong start to his U.S. Open title defence on Wednesday, dispatching France's Arthur Rinderknech 6-2, 7-5, 6-3 in the Arthur Ashe Stadium to reach the third round.
Serena Williams roared into the third round of the US Open on Wednesday, overpowering second seed Anett Kontaveit with a battling performance to extend her Grand Slam singles career in dramatic fashion.
Emma Raducanu's U.S. Open title defence ended at the first hurdle on Tuesday while Wimbledon champion Elena Rybakina and twice U.S. Open winner Naomi Osaka were also ousted in the opening round.
Defending champion Emma Raducanu of Britain was sent crashing out of the US Open in the first round on Tuesday, losing in straight sets to France's Alize Cornet.
Four-time champion Rafael Nadal overcame dropping the first set to defeat Australian wildcard Rinky Hijikata at the US Open first round on Tuesday.
Daniil Medevedev launched the defence of his US Open crown on Monday with a straight sets victory over lowly ranked American Stefan Kozlov.