With Roger Federer retired and Rafael Nadal struggling to get back on court due to injuries, Novak Djokovic was the last man of that golden generation standing at Flushing Meadows, but the Serb crashed out in the third round to Australian Alexei Popyrin.
Jannik Sinner produced a brutal display of baseline power as he became the first Italian man to win the US. Open with a 6-3, 6-4, 7-5 win over American Taylor Fritz in the final on Sunday.
"I'm speechless right now. So many times I thought I was so close to get the US Open title. It has always been a dream of mine and finally I got this beautiful trophy," said Sabalenka.
Frances Tiafoe blamed his heartbreaking five-set US Open semi-final defeat to Taylor Fritz on cramping after his "body shut down".
Taylor Fritz fought back to defeat compatriot Frances Tiafoe at the US Open on Friday, becoming the first American man to reach a Grand Slam final in 15 years.
Italian top seed Jannik Sinner took down ailing Briton Jack Draper 7-5, 7-6 (7/3), 6-2 to reach the US Open final on Friday, overcoming muggy conditions in a chaotic match at Arthur Ashe Stadium.
World number one Jannik Sinner reached his first US Open semi-final on Wednesday with a four-set victory over 2021 champion and two-time runner-up Daniil Medvedev.
Jessica Pegula became the fourth American to reach this year's US Open semifinals on Wednesday by stunning world number one Iga Swiatek as Jack Draper broke through to his first Grand Slam last-four.
Top seed Swiatek, who won the title two years ago, showcased her all-court game in a straightforward 6-4, 6-1 win over Russian Liudmila Samsonova to open the evening session at Arthur Ashe Stadium and warned she was only going to improve.
Colombian qualifier Daniel Galan stunned fourth-seeded Greek Stefanos Tsitsipas 6-0, 6-1, 3-6, 7-5 in an epic first-round showdown at the U.S. Open on Monday, winning the affair on the ninth match point.
Serena Williams said she is "staying vague" over her expected retirement from tennis after reaching the US Open second round on Monday.
After a glittering 27-year professional career in which she became one of the greatest players of all time, Serena Williams is preparing to bid farewell to tennis at the major where it all began.
A talented men's field is set for the 2022 U.S. Open, beginning on Monday. Flushing Meadows hosts the event with Rafael Nadal operating as the headline-grabbing player on the men's side.
Serena Williams held strong views on tennis, society as well as her rivals.
Rafael Nadal targets a fifth US Open and 23rd Grand Slam title in New York from next week with his path to the title no longer blocked by Novak Djokovic, whose refusal to get vaccinated has ruled him out of a second major this year.
Top seed Daniil Medvedev will open his U.S. Open title defence onMonday against American Stefan Kozlov but faces major hurdles on the path to a second Grand Slam title at Flushing Meadows, including in-form Australian Nick Kyrgios.
Serena Williams said on Tuesday she was "evolving away from tennis" and planned to retire from the sport she dominated with 23 Grand Slam titles following the U.S. Open tournament, which begins later this month.
Daniil Medvedev will arrive in New York for his U.S. Open title defence this month as the top seed after the Russian confirmed his stay as world number one by reaching the final in Los Cabos, Mexico on Friday.
Novak Djokovic said Saturday he is "preparing to compete" at the US Open even though his refusal to get vaccinated will see him barred from entering the country.