With Roger Federer retired and Rafael Nadal struggling to get back on court due to injuries, Novak Djokovic was the last man of that golden generation standing at Flushing Meadows, but the Serb crashed out in the third round to Australian Alexei Popyrin.
Jannik Sinner produced a brutal display of baseline power as he became the first Italian man to win the US. Open with a 6-3, 6-4, 7-5 win over American Taylor Fritz in the final on Sunday.
"I'm speechless right now. So many times I thought I was so close to get the US Open title. It has always been a dream of mine and finally I got this beautiful trophy," said Sabalenka.
Frances Tiafoe blamed his heartbreaking five-set US Open semi-final defeat to Taylor Fritz on cramping after his "body shut down".
Taylor Fritz fought back to defeat compatriot Frances Tiafoe at the US Open on Friday, becoming the first American man to reach a Grand Slam final in 15 years.
Italian top seed Jannik Sinner took down ailing Briton Jack Draper 7-5, 7-6 (7/3), 6-2 to reach the US Open final on Friday, overcoming muggy conditions in a chaotic match at Arthur Ashe Stadium.
World number one Jannik Sinner reached his first US Open semi-final on Wednesday with a four-set victory over 2021 champion and two-time runner-up Daniil Medvedev.
Jessica Pegula became the fourth American to reach this year's US Open semifinals on Wednesday by stunning world number one Iga Swiatek as Jack Draper broke through to his first Grand Slam last-four.
Top seed Swiatek, who won the title two years ago, showcased her all-court game in a straightforward 6-4, 6-1 win over Russian Liudmila Samsonova to open the evening session at Arthur Ashe Stadium and warned she was only going to improve.
Novak Djokovic was included on the entry list for the US Open on Wednesday but will not be able to compete due to his refusal to be vaccinated against COVID-19.
Recently-crowned Wimbledon champion Novak Djokovic said on Monday it is unlikely he will feature in this year's US Open as he continues to refuse to be vaccinated against coronavirus.
Canadian teenager Bianca Andreescu claimed her first Grand Slam title in a hard-hitting, nerve-jangling 6-3 7-5 win over Serena Williams on Saturday that put the brakes on the American's bid to equal the all-time record.
Nick Kyrgios was a lightning rod for controversy at the U.S. Open this week but the fiery Australian was subdued after a third-round loss on Saturday and walked away quietly from the year's final Grand Slam.
Roger Federer gave India's Sumit Nagal a harsh introduction to Grand Slam tennis as the five-time champion weathered an early storm for a 4-6, 6-1, 6-2, 6-4 win on Monday to reach the second round of the U.S. Open.
World number one Rafael Nadal's third U.S. Open and 16th grand slam title which he bagged with a 6-3 6-3 6-4 demolition of South African Kevin Anderson, triggers speculations on his chances of surpassing Federer's record of 19 major championships.
World number one Rafa Nadal's quest for a 16th grand slam title will lead to a barrage of big serves when he battles South African Kevin Anderson in a conflict of styles at the U.S. Open final.
Sloane Stephens stun two-times U.S. Open winner Venus Williams to ensure a new grand slam champion is crowned at the Flushing Meadows while Madison Keys hammer CoCo Vandeweghe to set up an all-American final.
Venus Williams vows to make amends for her Wimbledon final heartache by ending a bittersweet year on a high at the US Open.
Rickie Fowler produces a record-equalling low-scoring round to take a one-shot lead at the US Open as the big-hitters failed to fire.