A brace from Amad Diallo gave United their first success in this season's competition, coming under interim manager Ruud van Nistelrooy after they had drawn the previous three games with Erik ten Hag was in charge.
Tottenham Hotspur made it three wins from three in the Europa League with a 1-0 win at home to AZ on Thursday but Manchester United remain winless after being held to a 1-1 draw at red-carded Jose Mourinho's Fenerbahce.
Manchester United manager Erik ten Hag has highlighted a lack of goals as the major factor behind the English giants' faltering start to the season.
Manchester United manager Erik ten Hag said his side had failed to maintain their intensity in Wednesday's 1-1 Europa League draw with FC Twente and should have pushed to kill the visitors off before they had the chance to equalise.
Erik ten Hag made a convincing case to be spared the sack as Manchester United upset Manchester City to take the FA Cup with a shock 2-1 victory in Saturday's final.
Leverkusen - or 'Neverlusen' as they had been dubbed after obliterating Bayern Munich's 11-year Bundesliga title monopoly in Germany - can still win a domestic double with victory against second-tier Kaiserslautern in Saturday's German Cup final.
Gian Piero Gasperini lavished praise on his "incredible" Atalanta players after they stunned Bayer Leverkusen to win the Europa League and claim their first ever continental honour.
Ademola Lookman scored a stunning hattrick as Atalanta ended Bayer Leverkusen's 51-match unbeaten run to win the Europa League final 3-0 on Wednesday and claim their first trophy for 61 years.
Bayer Leverkusen had won only two major trophies in their 119-year history before this season but on Wednesday the newly-crowned Bundesliga champions have the chance to claim a double when they face Atalanta in the Europa League final in Dublin.
Brighton's "incredible" journey from homeless exiles facing oblivion to their current status as Premier League trendsetters will reach a memorable climax when they host AEK Athens in their first-ever European match on Thursday.
Liverpool were handed a kind draw on Friday for this season's Europa League group stage while their Premier League rivals Brighton and Hove Albion can look forward to meeting European giants Ajax and Marseille in their first ever foray into continental competition.
“I thank you for the invitation to join the UEFA Football Board, but I regret to inform you that I will be relinquishing my involvement with immediate effect,” Mourinho wrote in a letter to UEFA director and former AC Milan chairman Zvonimir Boban.
His message was one of pride, which is what he has restored at Roma, a team which has one of Italy's largest, most passionate fan bases but has won little of note since being founded in 1927.
Jose Mourinho threw his future as Roma manager into further doubt on Wednesday, saying he was "too tired" after the bitter pain of losing his first major European final to Sevilla.
Sevilla beat AS Roma 4-1 on penalties on Wednesday to win the Europa League for a record-extending seventh time, handing Jose Mourinho his first defeat in six European finals.
"The present is more important. The past is the past. We don't know the future," Mourinho said.
AS Roma grabbed a 1-0 home victory over Bayer Leverkusen in their Europa League semi-final first leg on Thursday thanks to 20-year-old Edoardo Bove's second-half goal.
Federico Gatti scored with a header seven minutes into added time to earn Juventus a 1-1 home draw against Sevilla in their Europa League semi-final first leg on Thursday.
Liverpool will take the chance to qualify for the Europa League as they look to squeeze everything out of a disappointing season, manager Juergen Klopp said ahead of Sunday's home Premier League game against Tottenham Hotspur.