For a club sitting 14th in the Premier League and sleepwalking towards their worst-ever points haul, this second-tier continental competition has become the only show in town.
Nowhere will those celebrations be bigger than inside the Arctic Circle in Bodo, where fans will now be preparing for a semi-final against English Premier League side Tottenham Hotspur after one of the greatest nights in Norwegian sport.
United's season looked over when Lyon came from 2-0 down to lead by two goals with just six minutes remaining at Old Trafford despite having captain Corentin Tolisso sent off.
Andre Onana will be recalled for Manchester United's season-defining Europa League quarter-final second leg against Lyon after his costly goalkeeping errors in the first leg, manager Ruben Amorim confirmed on Wednesday.
Manchester United goalkeeper Andre Onana has been dropped for Sunday’s Premier League match at Newcastle United after his mistakes led to both Olympique Lyon goals in a 2-2 draw in their Europa League quarter-final first leg on Thursday, British media said.
Manchester United captain Bruno Fernandes said it is not the players' fault for the contracts signed off by the club as he hit back at claims by co-owner Jim Ratcliffe that some are "overpaid".
Wayne Rooney thinks former side Manchester United look "lost" and "scared" on the pitch and that "10 to 15 players need to leave the club".
Real Sociedad's Mikel Oyarzabal coolly netted a penalty to hold Manchester United to a 1-1 draw in a Europa League last 16 first leg clash on Thursday.
Manchester United were drawn Friday to play Real Sociedad of Spain in the last 16 of this season's Europa League, while Rangers will take on Jose Mourinho's Fenerbahce, and Tottenham Hotspur face AZ Alkmaar.
"Disappointed that we did not go through but not frustrated or angry. Now we can focus on the league and that's what we will do," Klopp told reporters.
Last season's runners-up Roma advanced to their fourth European semi-final in a row.
Atalanta have a chance to make history on Thursday as they welcome Liverpool to Bergamo with one foot in the Europa League semi-finals thanks to a stunning first-leg win at Anfield.
Jurgen Klopp was headed for a glorious send-off in his final season at Liverpool just a few weeks ago, but talk of a potential quadruple is now long forgotten as the Reds have come off the rails.
"It just was a really bad game, oh my god. We started well, really well, and then didn't continue. I think even before they scored, we just lost the plot a little bit, we were everywhere and nowhere," Klopp told reporters.
Atalanta knocked out Portuguese side Sporting Lisbon in the previous round but have won just two of their last nine matches in all competitions.
Leverkusen head into Thursday's home first leg against West Ham in the Europa League quarter-finals unbeaten in 41 matches this season, with 36 wins and five draws.
Jurgen Klopp's Liverpool, who are still in contention to win a quadruple this season, will entertain Atalanta at Anfield on April 11 and go to Italy a week later for the return.
AC Milan, Marseille, Roma and West Ham were among the other sides to also book their place in Friday's quarter-final draw.
Liverpool remain on course to send Jurgen Klopp off with a quadruple.
